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Cake day: August 8th, 2023

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  • When you are talking about large molecules like biologics (antibodies, most vaccines, etc.), there are a whole bunch of other things that can go wrong, but not this.

    For protein based drugs there are prions: misfolded protein isoforms able to catalytically convert correctly folded proteins, basically following the same logic as the examples of smaller molecules. So far I guess we only know of one group of proteins that do this (like the mad cow disease one) but theoretically it could always happen to others we just don’t know about yet. :)

    Sorry if that made anyone feel worse again…