Not with that attitude.

And with a little CRISPR CAS-9, we can alter ourselves to become super-mutants or ghouls who can feed on ionizing radiation.

Then, finally, I’ll be ready for the postapocalyptic nuclear wasteland.

Darklight? Check

Flashlight? Check

Fleshlight? ( ͡° ͜ʖ ͡°) Check.

*takes another shot and melts into chair

“Captain, I can’t take much more of this!”

Thanks for clarifying.

I don’t think the people who are prone to attribute things to Satan have much overlap with the people who work in or adjacent to pharmaceuticles. Also, what do you mean “without anything to go on”, we know exactly what’s going on. That’s why we’re talking about it.

Regulatory? Nice to hear some of you survived till today. Good luck buddy, I’m rooting for you!

Me dropping my manuscript off to my agent.

I would pay my last kidney to see this for real at the La Scala Opera House in Milan.

Fun fact time because I’m that guy.

Coke and meth are similar in that they both activate stimulate Dopamine (reward, motivation), Norepinephrine (arousal, alertness) Serotonin (mood, modulation).

However they do it in very different ways:

Cocaine blocks neurotransmitter reuptake from the outside, it stops the neurotransmitter from being released from the synapse causing the area to flood and the synapse to fire more strongly, but still tied to normal stimulation. I.e. your body still produces the transmitter based on normal stimuli, coke just keeps it there longer, stretching the existing signal.

Methamphetamine drives release from the inside. It pushes dopamine out and into the synapse, and has some reuptake inhibition that combines drive the synapses far harder than normal. In contrast to coke, it doesn’t stretch existing signals from physiological stimuli, it makes signals regardless of what’s going on.

In short, coke blocks the sink’s drain. Meth turns on the tap and sorta plugs the drain. Slight advantage to meth here for ADHD. CNS depression that underlies it responds better to meth because the taps don’t open enough to begin with. Normal psysiological stimuli isn’t enough.

Both in theory could treat ADHD, but meth wins by a longshot because of the speed and stability of its pharmacokinetics. Coke is in and out too fast to give the user the therapeutic window of relief without causing spikes that trigger negatives like addiction or heart problems. Meth is slower and longer lasting. 20-60 mins for coke, ~4 hours for meth. Leveraging extended release (er) formulations pushes meths already superior action (turn on tap) into a daily therapeutic window, while coke is still just behaving like a party drug.

Source: Lots of personal research. ( ͡° ͜ʖ ͡°)

Ground beefillionaire. It’s surprisingly affordable, but for the best quality cuts, you have to work for it.

Arsenic? Cyanide? Don’t trust strangers on the internet. Do your own research! A blind taste test will settle this once and for all.

Never met a bean I didn’t love.

After the headline, but before the article I thought - Define “center” or Ellison’s, The Guardian’s and the public polls and opinions are worthless.

My second thought was here is another public figure trying to influence a public conversation whose only qualification is being so rich as to be completely out of touch with reality.

You’re all wrong! Fools!

Everyone knows it’s a Kirk era tricorder.

In Latvia you can’t cube impossible dream. Is cold.

Cube 2 potato. Toss in olive oil. Toss in 2 tablespoons minced garlic/garlic powder and like 2 tablespoons minced onion/onion powder, paprika, salt, oregano and minced rosemary. Toss again in bowl to evenly coat everything.

Spread on sheet. Roast at 325 for 22 mins or so until brown and crispy. Shread your favoutite cheeses on top and let them melt by heat from being fresh out of the oven.

I recommend mozza, sharp cheddar and parmagiano combo. Also consider parmagiano and pecorino combo.

Why does the Van Allen belt look so much like booty? Stupid sexy radiation.

So we can consider our sun dying and Andromeda colliding with the milky way as crappy backstops.5 billion years for a maybe is not great. I don’t know about you, but I don’t have that kind of patience. We need fresh ideas. I like your singularity idea, but getting crushed isn’t as artistically coherent as a quality shattering and if you’ve checked the price of singularities these days, its not really in the budget.

I think the most viable option I’ve heard so far is a mega asteroid. Do you know any suitable candidates for rent?

Ladies, Gentlemen, Nuclear Engineers, Aliens bent on conquest and demi-gods or demons bent on wrath and destruction; Look, we have a job to do. The earth probably isn’t going to shatter on its own. At least not with that attitude. We need teamwork. Collaboration. Hard math. Next, next-next-next-gen explosives and a lot of them.

We can do this!